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Chimeric RNAs reveal putative neoantigen peptides for developing tumor vaccines for breast cancer

IntroductionWe present here a strategy to identify immunogenic neoantigen candidates from unique amino acid sequences at the junctions of fusion proteins which can serve as targets in the development of tumor vaccines for the treatment of breastcancer.MethodWe mined the sequence reads of breast tumo...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Brandon Mistretta, Sakuni Rankothgedera, Micah Castillo, Mitchell Rao, Kimberly Holloway, Anjana Bhardwaj, Maha El Noafal, Constance Albarracin, Randa El-Zein, Hengameh Rezaei, Xiaoping Su, Rehan Akbani, Xiaoshan M. Shao, Brian J. Czerniecki, Rachel Karchin, Isabelle Bedrosian, Preethi H. Gunaratne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-09-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
RNA fusions
chimeric RNAs
neoantigens
immunopeptides
tumor peptide vaccines
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188831/full
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