Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity

Abstract Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need for strategies to increase cDC1 acces...

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Hlavní autoři:	Louise Gorline, Fillipe Luiz Rosa do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vetillard, Aboubacar Sidiki K Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, Zeina Abou Nader, Judith Weber, Hannah Theobald, Matthieu Collin, Joseph Calmette, Giorgio Anselmi, Flavia Fico, Florent Ginhoux, Laleh Majlessi, Emmanuel L. Gautier, Loredana Saveanu, Julie Helft, Marc Dalod, Mathilde Dusseaux, James P. Di Santo, Stéphanie Hugues, Pierre Guermonprez
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-12-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-68018-3
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!