Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly inhibiting Neuropeptide Y/Agouti-related pept...

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Detalhes bibliográficos

Principais autores:	Yanbin Dong, Jamie Carty, Nitsan Goldstein, Zhenyan He, Eunsang Hwang, Dominic Chau, Briana Wallace, Anita Kabahizi, Linh Lieu, Yunqian Peng, Yong Gao, Ling Hu, J. Nicholas Betley, Kevin W. Williams
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-12-01
coleção:	Molecular Metabolism
Assuntos:	Liraglutide and semaglutide Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs) TRPC5 subunit Metabolic state-dependent effects GLP-1R Agonists on NPY/AgRP neuron POMC Neuronal activity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221287782100199X
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