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Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/GPX4 Signaling to Inhibit Ferroptosis

Iron overload, a key driver of ferroptosis, results from excessive iron accumulation in tissues and contributes to organ injury, including renal dysfunction. Increasing evidence indicates that ferroptosis plays an important role in the pathogenesis of kidney diseases. Natural antioxidants capable of...

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Principais autores: Xiaoyi Wang, Wenmi Li, Wenzheng Yuan, Ziyu Wei, Zixuan Yang, Zichun Zhang, Zhibin Sun, Guojie Ji, Huanhuan Hu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2026-02-01
coleção:Life
Assuntos:
quercetin
kidney injury
iron overload
NRF2/xCT/GPX4
ferroptosis
Acesso em linha:https://www.mdpi.com/2075-1729/16/3/372
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