Predictive power of deleterious single amino acid changes to infer on AAV2 and AAV2-13 capsids fitness

Adeno-associated virus (AAV) is the most widely used vector for in vivo gene transfer. A major limitation of capsid engineering is the incomplete understanding of the consequences of multiple amino acid variations on AAV capsid stability resulting in high frequency of non-viable capsids. In this con...

詳細記述

書誌詳細

主要な著者:	Tiziana La Bella, Bérangère Bertin, Ante Mihaljevic, Justine Nozi, Patrice Vidal, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi, Giuseppe Ronzitti
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2024-09-01
シリーズ:	Molecular Therapy: Methods & Clinical Development
主題:	adeno-associated virus AAV vector wild-type variant prediction model fitness deleterious mutation
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2329050124001438
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!