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Acetate Promotes T Cell Effector Function during Glucose Restriction

Summary: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell function. For instance, cancer cells use acetate as...

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Principais autores: Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-05-01
coleção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124719304875
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