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Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds

The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), hu...

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Autori principali: Giorgio Facchetti, Michael S. Christodoulou, Lina Barragán Mendoza, Federico Cusinato, Lisa Dalla Via, Isabella Rimoldi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-11-01
Serie:Molecules
Soggetti:
Schiff bases
ROS production
mitochondrial damage
tetrahydroquinolines
antiproliferative activity
Accesso online:https://www.mdpi.com/1420-3049/25/23/5561
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