L-Glutamate enables the EGFR-MEK-ERK-mTFB2 axis to enhance mitochondrial biogenesis in intestinal stem cells

Abstract Background Intestinal stem cells (ISCs) sustain epithelial homeostasis through rapid mitochondrial metabolism, however, how they sense nutrient signals to regulate mitochondrial function remains unclear. Methods We examined the role of L-glutamate (Glu) in regulating cell mitochondrial bios...

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主要な著者:	Cai-xia Dou, Hao-zhan Qu, Ying-chao Qin, Xiao-fan Wang, Jia-yi Zhou, Xiu-qi Wang, Hui-chao Yan
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2025-10-01
シリーズ:	Stem Cell Research & Therapy
オンライン･アクセス:	https://doi.org/10.1186/s13287-025-04718-3
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