Inflammatory and glycolytic programs underpin a primed blood neutrophil state in patients with pneumonia

Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in the circulation in patients during infection. Here...

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Principais autores:	Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2023-07-01
Serija:	iScience
Teme:	Health sciences Immunology Medicine
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2589004223012580
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