Arg/Lys-containing IDRs are cryptic binding domains for ATP and nucleic acids that interplay to modulate LLPS
Probing ssDNA binding to TAR-DNA-binding protein-43 (TDP-43) prion-like domain (PLD) through NMR shows key interactions for nucleic acid to drive liquid-liquid phase separation (LLPS) of intrinsically-disordered proteins.
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| 主要な著者: | , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Portfolio
2022-12-01
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| シリーズ: | Communications Biology |
| オンライン･アクセス: | https://doi.org/10.1038/s42003-022-04293-w |
| タグ: |
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