Accurate tumor purity determination is critical for the analysis of homologous recombination deficiency (HRD)

Homologous recombination deficiency (HRD) is a predictive marker for response to poly (ADP-ribose) polymerase inhibitors (PARPi) in ovarian carcinoma. HRD scores have entered routine diagnostics, but the influence of algorithms, parameters and confounders has not been analyzed comprehensively.A seri...

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Détails bibliographiques

Auteurs principaux:	Michael Menzel, Volker Endris, Constantin Schwab, Klaus Kluck, Olaf Neumann, Susanne Beck, Markus Ball, Christian Schaaf, Stefan Fröhling, Peter Lichtner, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger, Jan Budczies
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2023-09-01
Collection:	Translational Oncology
Sujets:	Homologous recombination deficiency HRD Tumor purity Tumor cell content Whole exome sequencing WES
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S193652332300092X
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