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A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy responseResearch in context

Summary: Background: High-grade serous ovarian carcinoma (HGSOC) presents a significant therapeutic challenge. Late-stage disease is frequently associated with peritoneal carcinomatosis. The peritoneal metastases exhibit a unique tumour microenvironment (TME) distinct from the primary tumours and o...

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Principais autores: Christiane Helgestad Gjerde, Katrin Kleinmanns, Anika Langer, Gorka Ruiz de Garibay Ponce, Ezekiel Rozmus, Gina Nyhus Stangeland, Calum Leitch, Rammah Elnour, Harsh Nitin Dongre, Constantin Berger, Okan Gultekin, Christopher Forcados, Maria Stensland, Tuula Anneli Nyman, Kaisa Lehti, Ben Davidson, Sébastien Wälchli, Pascal Gelebart, Daniela Elena Costea, Spiros Kotopoulis, Line Bjørge, Emmet McCormack
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-02-01
coleção:EBioMedicine
Assuntos:
HGSOC
Peritoneal metastases
3D model
dECM scaffold
Proteomics
Drug sensitivity
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396426000162
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