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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

<p>Abstract</p> <p>Background</p> <p>Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human diseases such as cancer. We investigated the role of KDM5B,...

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Principais autores: Kelly John D, Field Helen I, Tsunoda Tatsuhiko, Iwai Yukiko, Unoki Motoko, Veerakumarasivam Abhimanyu, Yoshimatsu Masanori, Hayami Shinya, Neal David E, Yamaue Hiroki, Ponder Bruce AJ, Nakamura Yusuke, Hamamoto Ryuji
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2010-03-01
Serier:Molecular Cancer
Online adgang:http://www.molecular-cancer.com/content/9/1/59
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