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Preparation and purification of novel phosphatidyl prodrug and performance modulation of phosphatidyl nanoprodrug

Abstract Background A novel phosphatidyl nanoprodrug system can be selectively released parent drugs in cancer cells, triggered by the local overexpression of phospholipase D (PLD). This system significantly reduces the intrinsic disadvantages of conventional chemotherapeutic drugs. However, the sep...

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Principais autores: Rui Niu, PeiLei Zhang, Feng-Qing Wang, Min Liu, QingHai Liu, Ning Jia, ShengLi Yang, XinYi Tao, DongZhi Wei
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2019-11-01
Serier:Bioresources and Bioprocessing
Fag:
Phosphatidyl prodrug
Purification
Gradient elution
Silica gel column chromatography
PEGylation
RGD modification
Online adgang:http://link.springer.com/article/10.1186/s40643-019-0277-1
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