Hypoxia-induced MT2A-tetrameric PKM2 interaction maintains PKM2 activity in a copper-ion-dependent manner

Hypoxia is a hallmark of solid tumors associated with tumor malignancy. Mitochondrial metabolic reprogramming is a key step in the process of cellular adaptation to hypoxic stress for tumor growth, but the regulatory mechanisms are not fully understood. In this study, through mitochondrial proteomic...

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Huvudupphovsmän: Ronghui Gao, Qifang Li, Jiahao Guo, Zirou Peng, Chuan Gao, Zirui Zhou, Hankun Hu, Jing Zhang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2025-12-01
Serie:Cell Insight
Ämnen:
Mitochondrial translocation
Hypoxia
MT2A
Copper ion
PKM2
Breast cancer growth
Länkar:http://www.sciencedirect.com/science/article/pii/S2772892725000513
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