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Transcriptional landscape of pleural mesothelioma patients in relation to NF2 gene mutational status

Abstract Background Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis, often driven by asbestos exposure. Mutations in the NF2 gene, a key regulator of the Hippo signaling pathway, are frequently observed in PM. However, their impact on tumor biology, immune infiltration, cytokin...

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Principais autores: Carlos Orozco-Castaño, Alejandro Mejía-Garcia, Hsuan Megan Tsao, Diego A. Bonilla, Carlos Carvajal-Fierro, Ricardo Bruges-Maya, Alba Combita, Rafael Parra-Medina
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2025-06-01
coleção:Journal of the Egyptian National Cancer Institute
Assuntos:
Pleural mesothelioma
NF2 mutations
Transcriptome analysis
Chemotherapeutic response
Immune infiltration
Personalized therapy
Acesso em linha:https://doi.org/10.1186/s43046-025-00284-0
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