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The toxicokinetic profile of Dex40-GTMAC3 - a novel polysaccharide candidate for reversal of unfractionated heparin.

Though protamine sulfate is the only approved antidote of unfractionated heparin (UFH), yet may produce life threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. We have described 40 kDa dextrans (Dex40) substituted with glycidyltrimet...

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Asıl Yazarlar: Emilia eSokolowska, Bartlomiej eKalaska, Kamil eKaminski, Alicja eLewandowska, Agnieszka eBlazejczyk, Joanna eWietrzyk, Irena eKasacka, Krzysztof eSzczubialka, Dariusz ePawlak, Maria eNowakowska, Andrzej eMogielnicki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2016-03-01
Seri Bilgileri:Frontiers in Pharmacology
Konular:
Heparin
Safety
Toxicity
toxicokinetics
Protamine sulfate
Dextran
Online Erişim:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00060/full
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