People with cystic fibrosis with high sputum neutrophil elastase on elexacaftor-tezacaftor-ivacaftor exhibit worse pulmonary function and pro-inflammatory airway milieu

Abstract Cystic fibrosis (CF) is a genetic condition affecting over 100,000 individuals worldwide. Lung disease is the main cause of mortality in CF, with chronic neutrophilic inflammation as a hallmark. Elexacaftor/tezacaftor/ivacaftor (ETI) is a combination of highly effective CF transmembrane con...

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Auteurs principaux:	Alexandre Cammarata-Mouchtouris, Diego Moncada Giraldo, Genoah L. Collins, Maria M. Parrilla, Susan O. Kim, Sarah Mansour, Vincent D. Giacalone, Kirsten A. Cottrill, Rabindra Tirouvanziam, Joshua D. Chandler
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2025-12-01
Collection:	Scientific Reports
Sujets:	Cystic fibrosis CFTR modulators Neutrophil elastase Sputum Lung function Lung inflammation
Accès en ligne:	https://doi.org/10.1038/s41598-025-26263-y
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