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Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway

Purpose: This study is designed to explore whether Fructus ligustri lucidi (FLL) exhibits antioxidant effect in ovariectomized (OVX) rats, and to identify the signaling pathway involved in this process.Methods: OVX rats were treated with FLL aqueous extract (3.5 g/kg) for 12 weeks. Serum, uteri, and...

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Main Authors: Lili Wang, Rufeng Ma, Yubo Guo, Jing Sun, Haixia Liu, Ruyuan Zhu, Chenyue Liu, Jun Li, Lin Li, Beibei Chen, Liping Sun, Jinfa Tang, Dandan Zhao, Fangfang Mo, Jianzhao Niu, Guangjian Jiang, Min Fu, Dieter Brömme, Dongwei Zhang, Sihua Gao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
Fructus Ligustri Lucidi
ovariectomy
NADPH oxidase 4 (Nox4)
nuclear factor kappa B (NF-κB)
oxidative stress
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00266/full
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