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Human Germline Biallelic Loss-of-Function OSMR Variants Cause Severe Allergic Disease

IntroductionOSMR encodes oncostatin M receptor beta (OSMRβ), a cell surface receptor of the gp130 family that binds OSM and IL-31, and is highly expressed on fibroblasts. The gp130 family comprises signaling proteins, many of which have been linked to primary atopic disorders (PAD).MethodsWe have be...

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Principais autores: Simran Samra, Mehul Sharma, Julia Körholz, Kate L. Del Bel, Yihui Liu, Alyssa E. James, Sergio Rosenzweig, Julie Niemela, P M Prathibha, Oliver Wegehaupt, Sateesh Maddirevula, Siddaramappa J. Patil, Diana K. Bayer, Jonathan J. Lyons, Stuart E. Turvey
פורמט: Artigo
שפה:Inglês
יצא לאור: Rockefeller University Press 2026-05-01
סדרה:Journal of Human Immunity
גישה מקוונת:https://rupress.org/jhi/article/2/CIS2026/eCIS2026abstract.11/281876/Human-Germline-Biallelic-Loss-of-Function-OSMR
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