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Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergismsResearch in context

Summary: Background: Pharmacological synergisms are an attractive anticancer strategy. However, with more than 5000 approved-drugs and compounds in clinical development, identifying synergistic treatments represents a major challenge. Methods: High-throughput screening was combined with target deco...

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Principais autores: Jérémy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Kevin Muller, Guillaume Pinna, Tim W. Failes, Greg M. Arndt, Philippe Morando, Nathalie Baeza-Kallee, Carole Colin, Olivier Chinot, Diane Braguer, Xavier Morelli, Nicolas André, Manon Carré, Emeline Tabouret, Dominique Figarella-Branger, Marion Le Grand, Eddy Pasquier
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:EBioMedicine
Fag:
Drug combination screening
Target deconvolution
Pharmacological synergisms
Glioblastoma
Cancer vulnerabilities
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396423003171
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