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Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing Phenylethynyl Pyrazole Side Chains

A series of triazole derivatives containing phenylethynyl pyrazole moiety as side chain were designed, synthesized, and most of them exhibited good in vitro antifungal activities. Especially, compounds <b>5k</b> and <b>6c</b> showed excellent in vitro activities against <i>C. albicans</i> (MIC = 0.1...

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Principais autores: Tingjunhong Ni, Zichao Ding, Fei Xie, Yumeng Hao, Junhe Bao, Jingxiang Zhang, Shichong Yu, Yuanying Jiang, Dazhi Zhang
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-05-01
Series:Molecules
Assuntos:
triazole
CYP51
antifungal
molecular docking
synthesis
Acceso en liña:https://www.mdpi.com/1420-3049/27/11/3370
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