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GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function

Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic β-cell function and prevent type 2 diabetes (T...

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I tiakina i:
Ngā kaituhi matua: Gregory Austin, Affiong I. Oqua, Liliane El Eid, Mingli Zhu, Yusman Manchanda, Priyanka Peres, Helena Coyle, Yelyzaveta Poliakova, Zhanna Balkhiyarova, Karim Bouzakri, Alex Montoya, Dominic J. Withers, Michele Solimena, Ben Jones, Steven J. Millership, Steffen Burgold, David C. A. Gaboriau, Endre Majorovits, Evelyn Garlick, Maria Augusta do R. B. F. Lima, Inga Prokopenko, Jonathon Nixon-Abell, Andreas Müller, Alejandra Tomas
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2025-12-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-025-66115-x
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