Pediatric pharmacokinetics and pharmacodynamics of guanabenz for the treatment of vanishing white matter
Abstract Vanishing White Matter (VWM) is a leukodystrophy with cystic cerebral white matter degeneration, resulting in neurological decline and premature death. There is currently no treatment. Guanabenz, a central α2-adrenergic receptor agonist, ameliorates the disease in VWM mouse models. We aimed...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Portfolio
2026-06-01
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| Σειρά: | Scientific Reports |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1038/s41598-026-47959-9 |
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