Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1‐ETO mouse model

Abstract The t(8;21) chromosomal translocation activates aberrant expression of the AML1‐ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expr...

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Hlavní autoři:	Nina Cabezas‐Wallscheid, Victoria Eichwald, Jos de Graaf, Martin Löwer, Hans‐Anton Lehr, Andreas Kreft, Leonid Eshkind, Andreas Hildebrandt, Yasmin Abassi, Rosario Heck, Anna Katharina Dehof, Svetlana Ohngemach, Rolf Sprengel, Simone Wörtge, Steffen Schmitt, Johannes Lotz, Claudius Meyer, Thomas Kindler, Dong‐Er Zhang, Bernd Kaina, John C. Castle, Andreas Trumpp, Ugur Sahin, Ernesto Bockamp
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2013-10-01
Edice:	EMBO Molecular Medicine
Témata:	cancer stem cells core binding factor acute myeloid leukaemia preclinical mouse model therapy target validation whole transcriptome sequencing
On-line přístup:	https://doi.org/10.1002/emmm.201302661
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