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What have we learned about TP53-mutated acute myeloid leukemia?

Abstract TP53 is a tumor suppressor gene frequently mutated in human cancers and is generally associated with poor outcomes. TP53 mutations are found in approximately 5% to 10% of patients with de novo acute myeloid leukemia (AML), more frequently observed in elderly patients and those with therapy-...

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Hlavní autoři: Moazzam Shahzad, Muhammad Kashif Amin, Naval G. Daver, Mithun Vinod Shah, Devendra Hiwase, Daniel A. Arber, Mohamed A. Kharfan-Dabaja, Talha Badar
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2024-11-01
Edice:Blood Cancer Journal
On-line přístup:https://doi.org/10.1038/s41408-024-01186-5
Tagy: Přidat tag
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