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Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition

Oxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products. We describe here the formation of spirooxindoles using an intermolecular nitrone cycloaddition reaction. The nitrone dipole was prepared in situ...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Hauptverfasser: Beth L. Ritchie, Alexandra Longcake, Iain Coldham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2025-09-01
Schriftenreihe:Beilstein Journal of Organic Chemistry
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Online-Zugang:https://doi.org/10.3762/bjoc.21.146
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