Zigakibart Potently Inhibits A Proliferation-Inducing Ligand-Mediated IgA Production, Addressing IgAN Pathogenesis Root Causes

Introduction: Zigakibart is a humanized IgG4 monoclonal antibody (mAb) binding A proliferation-inducing ligand (APRIL, TNFSF13), a critical factor in IgA nephropathy (IgAN) pathogenesis. Results from the ongoing phase 1/2 ADU-CL-19 study (NCT03945318) have shown clinically meaningful outcomes in pat...

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Hlavní autoři:	John Dulos, Joost Kreijtz, Paul Vink, Victoria Cotton, Jay J. Kuo, Jeannette Lo, Wout Jansen, Jeroen Bakker, Lilian Driessen, Marco Guadagnoli, Peter van Zandvoort, Max Warncke, Jan Paul Medema, Jonathan Barratt, Hans van Eenennaam, Andrea Van Elsas
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-06-01
Edice:	Kidney International Reports
Témata:	antibody APRIL/TNFSF13 IgA nephropathy mode of action plasma cells zigakibart
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2468024926027488
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