Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies

Abstract Designing and carrying out a controlled human infection (CHI) model for hepatitis C virus (HCV) is critical for vaccine development. However, key considerations for a CHI model protocol include understanding of the earliest viral-host kinetic events during the acute phase and susceptibility...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Zhenzhen Shi, Adquate Mhlanga, Yuji Ishida, Ari Josephson, Nicholson T. Collier, Hiromi Abe-Chayama, Chise Tateno-Mukaidani, Scott J. Cotler, Jonathan Ozik, Marian Major, Jordan J. Feld, Kazuaki Chayama, Harel Dahari
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-12-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Hepatitis C virus Agent-based modeling Ordinary differential equations Liver-humanized mouse model Controlled human infection model
Online-Zugang:	https://doi.org/10.1038/s41598-024-83104-0
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