DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor

HPV-independent head and neck squamous cell carcinoma (HNSCC) is a common cancer globally. The overall response rate to anti-PD1 checkpoint inhibitors (CPIs) in HNSCC is ~16%. One major factor influencing the effectiveness of CPI is the level of tumor infiltrating T cells (TILs). Converting TILlow t...

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मुख्य लेखकों:	Chuan Wang, Nur Syafinaz Zainal, San Jiun Chai, James Dickie, Chai Phei Gan, Natasha Zulaziz, Bryan Kit Weng Lye, Ruhcha V. Sutavani, Christian H. Ottensmeier, Emma V. King, Mannil Thomas Abraham, Siti Mazlipah binti Ismail, Shin Hin Lau, Thomas George Kallarakkal, Kein Seong Mun, Rosnah binti Zain, Zainal Ariff Abdul Rahman, Gareth J. Thomas, Sok Ching Cheong, Natalia Savelyeva, Kue Peng Lim
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2021-10-01
श्रृंखला:	Frontiers in Immunology
विषय:	DNA vaccine cancer immunotherapy head and neck cancer MAGED4B FJX1 cancer antigens
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.763086/full
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