Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma

BackgroundRenal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%). 75% of the RCC cases involve conventional clear cell RCC (ccRCC). Approximately, 39% of late-stage patients (stage IV) are treated with chemotherapeutic agents. Phosphatidylinositol-3-kinase (PI3K) and Mitogen-Activ...

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Autori principali:	Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Mildred Acevedo-Duncan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-01-01
Serie:	Frontiers in Oncology
Soggetti:	renal cell carcinoma ICA-1 BYL719 PKC-ι PKC-ζ apoptosis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1213715/full
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