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Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis

Background & Aims: Expression of P21, encoded by the CDKN1A gene, has been associated with fibrosis progression in steatotic liver disease (SLD); however, the underlying mechanisms remain unknown. In the present study, we investigated the function of CDKN1A in SLD. Methods: CDKN1A expression lev...

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Principais autores: Arantza Lamas-Paz, Alejandro Hionides-Gutiérrez, Feifei Guo, Gonzalo Jorquera, Laura Morán-Blanco, Raquel Benedé-Ubieto, Mariana Mesquita, Olga Estévez-Vázquez, Kang Zheng, Marina Mazariegos, Elena Vázquez-Ogando, Elena Blázquez-López, Iris Asensio, Beste Mutlu, Beatriz Gomez-Santos, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Teresa C. Delgado, María Luz Martínez-Chantar, Eduardo Martínez-Naves, Carlos Sanz-García, Mohamed Ramadan Mohamed, Sofía Tesolato, Pilar Iniesta, Rocío Gallego-Durán, Douglas Maya-Miles, Javier Ampuero, Manuel Romero-Gómez, Ana Martínez-Alcocer, David Sanfeliu-Redondo, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andrea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, Matías A. Ávila, Maria Dolores Frutos, Carlos Manuel Martínez-Cáceres, Bruno Ramos-Molina, Patricia Aspichueta, Pere Puigserver, Yulia A. Nevzorova, Francisco Javier Cubero
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-01-01
coleção:JHEP Reports
Assuntos:
CDKN1A
Steatotic liver disease (SLD)
Hepatocyte
Senescence
Metabolic dysregulation
Palbociclib
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589555924002349
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