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Whole-exome sequencing of kidney transplant recipients and donors: insights into end-stage renal disease and post-transplant genetic risk

Abstract Background Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), yet challenges persist in long-term graft survival and post-transplant complications. Genomic profiling, especially whole-exome sequencing (WES), offers new opportunities to personalize donor-re...

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Principais autores: Mirgul Bayanova, Aidos Bolatov, Dias Malik, Malika Sapargaliyeva, Aizhan Abdikadirova, Aida Zhenissova, Lyazzat Nazarova, Mels Assykbayev, Saitkarim Abdugafarov, Saltanat Rakhimzhanova, Deniza Suleimenova, Gani Kuttymuratov, Ardak Ainakulov, Aliya Sailybayeva, Sholpan Altynova, Yuriy Pya
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:BMC Nephrology
Assuntos:
Kidney transplantation
Whole-exome sequencing
End-stage renal disease
Transplant morbidity
Allograft rejection
Precision medicine
Acesso em linha:https://doi.org/10.1186/s12882-025-04553-x
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