SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer

Abstract Background Biliary tract cancer is a group of highly heterogeneous and metastatic malignancies of the biliary tract. Current clinical treatment strategies and diagnostic methods need further improvement to effectively manage this disease. Methods We performed multiomics integrative and in s...

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Principais autores:	Yu-Yu Lin, Han-Hsi Kuo, Zhao-Jing He, Hsin-Yi Chung, Cheorl-Ho Kim, Yi-Ru Pan, Meng-Ju Wu, Ming-Hsien Chan, Chun-Nan Yeh, Nai-Jung Chiang, Ming-Huang Chen, Yu-Chan Chang
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-01-01
Series:	Cellular & Molecular Biology Letters
Assuntos:	Biliary tract cancer SLC25A11 Mitochondrial homeostasis NRF2 Ferroptosis
Acceso en liña:	https://doi.org/10.1186/s11658-025-00843-2
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