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Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

ABSTRACT The brain and liver are both critical organs involved in the pathogenesis of Alzheimer's disease (AD), particularly in the modulation of amyloid‐beta (Aβ) metabolism and neuroinflammation. Based on this, a multifunctional nanodrug delivery system, termed OAF, was developed by encapsulating...

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Principais autores: Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2026-06-01
Series:Advanced Science
Assuntos:
Alzheimer's disease
apoferritin
brain and liver dual‐targeting
multifunctional nanoparticle
oridonin
Acceso en liña:https://doi.org/10.1002/advs.202523458
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