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Protein kinase CK2: a potential therapeutic target for diverse human diseases

Abstract CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other we...

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Hauptverfasser: Christian Borgo, Claudio D’Amore, Stefania Sarno, Mauro Salvi, Maria Ruzzene
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2021-05-01
Schriftenreihe:Signal Transduction and Targeted Therapy
Online-Zugang:https://doi.org/10.1038/s41392-021-00567-7
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