Safety toxicology of an IL-2 ‘no-alpha’ mutein in the Sprague-Dawley rat following repeated dosing via intravenous administration

The potential toxicity, safety and anti-drug antibody production of the novel IL-2 “no-alpha” mutein is in need of investigation as it may be a critical candidate for cancer therapy. The design of this mutein is meant to reduce toxicity compared to the IL-2 wildtype by disrupting interactions with t...

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Autori principali:	Gokulan Nagabaskaran, Aaron Thambiahpillay, Nuris Ledon, Richard Bagshaw, Sum Lai Lozada, Gabriela Rivas, Kalet Leon, Albert Licollari
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-06-01
Serie:	Toxicology Reports
Soggetti:	Interleukin-2 mutein Toxicity High dose therapy Immune-related toxicities Cancer Safety issues
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221475002500157X
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