Targeting neurons in the gastrointestinal tract to treat Parkinson's disease

Background: Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through this mechanism suppresses aggregation of αS monomers in...

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Autores principales:	Robert A. Hauser, Dean Sutherland, Juan A. Madrid, Maria Angeles Rol, Steven Frucht, Stuart Isaacson, Fernando Pagan, Brian N. Maddux, George Li, Winona Tse, Benjamin L. Walter, Rajeev Kumar, Daniel Kremens, Mark F. Lew, Aaron Ellenbogen, Odinachi Oguh, Alberto Vasquez, William Kinney, Matt Lowery, Maria Resnick, Nicole Huff, Jerry Posner, Karla V. Ballman, Brian E. Harvey, Michael Camilleri, Michael Zasloff, Denise Barbut
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2019-01-01
Colección:	Clinical Parkinsonism & Related Disorders
Materias:	Squalamine ENT-01 Parkinson's disease Constipation Treatment Non-motor
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2590112519300015
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