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Natural and Modified Oligonucleotide Sequences Show Distinct Strand Displacement Kinetics and These Are Affected Further by Molecular Crowders

DNA and RNA strand exchange is a process of fundamental importance in biology. Herein, we used a FRET-based assay to investigate, for the first time, the stand exchange kinetics of natural DNA, natural RNA, and locked nucleic acid (LNA)-modified DNA sequences in vitro in PBS in the absence or presen...

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Autors principals: Ivana Domljanovic, Alessandro Ianiro, Curzio Rüegg, Michael Mayer, Maria Taskova
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2022-09-01
Col·lecció:Biomolecules
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Accés en línia:https://www.mdpi.com/2218-273X/12/9/1249
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