Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis

Background: Diabetes increases ischemic heart injury via incompletely understood mechanisms. We recently reported that diabetic adipocytes-derived small extracellular vesicles (sEV) exacerbate myocardial reperfusion (MI/R) injury by promoting cardiomyocyte apoptosis. Combining in vitro mechanistic i...

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Bibliografische Detailangaben

Hauptverfasser:	Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-02-01
Schriftenreihe:	Redox Biology
Schlagworte:	Apoptosis Diabetes Extracellular vesicle Myocardial ischemia/reperfusion injury
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S221323172400421X
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