Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition

Abstract Outer membrane proteins (OMPs) produced by Gram-negative bacteria contain a cylindrical amphipathic β-sheet (“β-barrel”) that functions as a membrane spanning domain. The assembly (folding and membrane insertion) of OMPs is mediated by the heterooligomeric β-barrel assembly machine (BAM). T...

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Principais autores:	Morgan E. Walker, Wei Zhu, Janine H. Peterson, Hao Wang, Jon Patteson, Aileen Soriano, Han Zhang, Todd Mayhood, Yan Hou, Samaneh Mesbahi-Vasey, Meigang Gu, John Frost, Jun Lu, Jennifer Johnston, Christopher Hipolito, Songnian Lin, Ronald E. Painter, Daniel Klein, Abbas Walji, Adam Weinglass, Terri M. Kelly, Adrian Saldanha, Jeffrey Schubert, Harris D. Bernstein, Scott S. Walker
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-04-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-58086-w
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