High interferon response signatures in SLE patient leukocytes are associated with increased transposable element expression in gene introns and intergenic regions

Abstract Background Systemic lupus erythematosus (SLE) is a spontaneous systemic auto-immune condition for which the inciting factors and genetic basis are generally unknown. Although heterogeneous in its manifestations and severity, SLE involves chronic inflammation along with sustained autoantibod...

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Hauptverfasser:	Leo J. Arteaga-Vazquez, Hugo Sepulveda, Bruno Villalobos Reveles, Kazumasa Suzuki, Kenneth C. Kalunian, Ferhat Ay, Mark R. Boothby, Anjana Rao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Mobile DNA
Schlagworte:	Transposable elements Systemic lupus erythematosus Neutrophils Inflammation Autoimmunity
Online-Zugang:	https://doi.org/10.1186/s13100-025-00377-6
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