Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells

Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxici...

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Main Authors:	Renata C. Costa de Freitas, Raul H. Bortolin, Mariana B. Lopes, Letícia Tamborlin, Letícia Meneguello, Vivian N. Silbiger, Rosario D. C. Hirata, Mário H. Hirata, Augusto D. Luchessi, André D. Luchessi
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2017-12-01
Series:	Frontiers in Pharmacology
Subjects:	clopidogrel microRNAs hepatotoxicity HepG2 cell line
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00906/full
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