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The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study

Abstract Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and induce headache and migraine. Our objective was t...

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Principais autores: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin, Messoud Ashina
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-05-01
Serier:The Journal of Headache and Pain
Fag:
Migraine
Pituitary adenylate cyclase-activating polypeptide
Migraine disorders
Monoclonal antibody
Migraine treatment
Online adgang:https://doi.org/10.1186/s10194-023-01599-w
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