Generation of exogenous kidneys via CRISPR/Cas9 mediated blastocyst complementation targeting Osr1 gene in mice

Abstract Blastocyst complementation has been reported to produce exogenous mouse organs including the pancreas, lungs, and kidneys, but the complemented kidneys still failed to rescue the host animals. In the present study, we generated mouse complemented kidneys through a two-step procedure: using...

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Bibliografische Detailangaben

Hauptverfasser:	Ting-Yu Yeh, Ing-Ming Chiu, Yu-Jia Huang, Shinn-Chih Wu, Chia-Chun Hsieh, Hsiang-Hsuan Sung, Wuh-Liang Hwu, Gou-Jen Wang, Jyh-Cherng Ju
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-11-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Blastocyst complementation Chimera Embryonic stem cells Nephrogenesis Osr1
Online-Zugang:	https://doi.org/10.1038/s41598-025-22373-9
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