Aspartame may promote erectile dysfunction via DPP4-mediated endothelial dysfunction and apoptosis: evidence from network toxicology, molecular dynamics simulation, and experimental validation

BackgroundAspartame is one of the most widely used artificial sweeteners, but its potential adverse effects on male reproductive health remain insufficiently understood. This study aimed to investigate the potential mechanisms by which aspartame may contribute to Erectile dysfunction (ED).MethodsPot...

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Hauptverfasser:	Zhiqiang Dai, Shouqiang Wang, Zhigui Chen, Qiang Zhang, Boyi Wang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-06-01
Schriftenreihe:	Frontiers in Nutrition
Schlagworte:	aspartame erectile dysfunction food safety network toxicology reproductive toxicology
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnut.2026.1841453/full
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