Tumor marker–guided precision BNCT for CA19-9–positive cancers: a new paradigm in molecularly targeted chemoradiation therapy

Abstract Background Boron neutron capture therapy (BNCT) is a molecularly targeted chemoradiation modality that relies on boron delivery agents such as p-borophenylalanine (BPA), which require LAT1 (L-type amino acid transporter 1) for tumor uptake. However, the limited efficacy of BPA in LAT1-low t...

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Hlavní autoři:	Noriyuki Kanehira, Fuminori Teraishi, Tomoyuki Tajima, Tatsunori Osone, Kazuyoshi Gotoh, Takuya Fujimoto, Yoshinori Sakurai, Natsuko Kondo, Narikazu Nagahisa, Kaoru Kamei, Taiga Fujita, Akira Morihara, Yutaka Takaguchi, Mizuki Kitamatsu, Takeshi Takarada, Kunitoshi Shigeyasu, Minoru Suzuki, Toshiyoshi Fujiwara, Hiroyuki Michiue
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	Journal of Translational Medicine
Témata:	Boron neutron capture therapy (BNCT) Precision BNCT Fucose-conjugated medicine CA19-9 Drug discovery
On-line přístup:	https://doi.org/10.1186/s12967-025-07349-7
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