Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)

The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP^Sc-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-induced toxicity...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	V. Villa, A. Corsaro, S. Thellung, A. Simi, M. Nizzari, M. Tonelli, V. Boido, A. Aceto, T. Florio
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	PAGEPress Publications 2011-01-01
Sarja:	Journal of Biological Research
Aiheet:	prion protein, quinacrine, minocycline
Linkit:	http://www.pagepressjournals.org/index.php/jbr/article/view/4689
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