The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers

G protein gated inward rectifier potassium (GIRK) channels are gated by direct binding of G protein beta-gamma subunits (Gβγ), signaling lipids, and intracellular Na+. In cardiac pacemaker cells, hetero-tetramer GIRK1/4 channels and homo-tetramer GIRK4 channels play a central role in parasympathetic...

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Detalhes bibliográficos

Principais autores:	Kouki K Touhara, Weiwei Wang, Roderick MacKinnon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2016-04-01
coleção:	eLife
Assuntos:	G protein gated potassium channel G protein hetero-tetrameric ion channel planar lipid bilayer cardiac physiology sodium activation
Acesso em linha:	https://elifesciences.org/articles/15750
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