Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri.

Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans. The high mortality rate of PAM (exceeding 97%) is attributed to (i) delayed diagnosis, (ii) lack of safe and effective anti-N....

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Wenxu Zhou, Anjan Debnath, Gareth Jennings, Hye Jee Hahn, Boden H Vanderloop, Minu Chaudhuri, W David Nes, Larissa M Podust
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Public Library of Science (PLoS) 2018-09-01
श्रृंखला:	PLoS Pathogens
ऑनलाइन पहुंच:	http://europepmc.org/articles/PMC6136796?pdf=render
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